Fractal Pharmacokinetics
نویسندگان
چکیده
منابع مشابه
Fractal Pharmacokinetics
Pharmacokinetics (PK) has been traditionally dealt with under the homogeneity assumption. However, biological systems are nowadays comprehensively understood as being inherently fractal. Specifically, the microenvironments where drug molecules interact with membrane interfaces, metabolic enzymes or pharmacological receptors, are unanimously recognized as unstirred, space-restricted, heterogeneo...
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24 Background : Despite recent advances in hepatitis C virus (HCV) therapeutics, the combination 25 of pegylated interferon (PEGIFN) and ribavirin (RBV) remains the cornerstone of treatment. 26 Optimization and individualization of PEGIFN dosing could improve outcomes. 27 Methods: Week one PEGIFN serum concentrations in 42 HCV genotype 1 infected patients 28 treated with conventional PEGIFN/RBV...
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ژورنال
عنوان ژورنال: Computational and Mathematical Methods in Medicine
سال: 2010
ISSN: 1748-670X,1748-6718
DOI: 10.1080/17486700903029280